I too started mostly in live home games / card rooms, then made it to online and casinos.
Differences for the most part have been discussed. Counting the size of the pot is a main issue, and physical tells is the other.
I found by carefully paying attention to players, there are a lot of tells you can pick up if you are looking for them (different facial expressions, betting patterns, glancing at chips, reaching then checking, time taken to bet etc). I also find it easier to make generalizations about a player after sitting with them for a while when I can actually see them, rather than a circle with a picture.
The play is less loose live as well (generally) calling a large bet is harder than clicking call.
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"Most of the money you'll win at poker comes not from the brilliance of your own play, but from the ineptitude of your opponents."
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