As long as you have enough to cap every street the whole way down, you're good to go. That's 4 small bets preflop + 4 small bets on the flop + 4 big bets on each the turn and river = 12 big bets total.
I typically buy in for the "suggested" amount, which is 25 big bets for most sites, and then reload as necessary if I drop below the magic 12 big bet mark.
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