They are just different games, I think it would be difficult. You can bluff people at $2/4, but at $.50/1, it's alot harder. (Agree?) I would certainly get confused, especially if I'm running more than two tables.
When multi-tabling, I *try* to stick to the same limit. I'll even go so far as to TRY to pick the same table w/ the same $$/hand, but that changes constantly.
I multi w/ SnG tournaments, but if it's a short-handed cash game, or a large MTT, I try to just focus on one thing. I think there is so much to be said about actually "watching" what the other players do. It definitely helps when you have to act in certain situations.
Clear that bonus - and don't lose too much.