In my limited experience, they seem to be filled with people that really don't know what they are doing HU. Because of that, I do think that a much higher winrate is possible at HU than anything else (although the variance can be cruel). Like 80% of the people I seem to face never fold to 3bets preflop (hugely exploitable) and/or have some big timing tells. For an example of a timing tell in action...
FullTiltPoker Game #1364125104: Table Spoon (heads up) - $3/$6 - No Limit Hold'em - 18:00:19 ET - 2006/12/06
Seat 1: MaXXXstaKd ($1,056)
Seat 2: aixelsyd ta lol ($667.50)
MaXXXstaKd posts the small blind of $3
aixelsyd ta lol posts the big blind of $6
The button is in seat #1
*** HOLE CARDS ***
Dealt to aixelsyd ta lol [6s 6d]
MaXXXstaKd raises to $18
aixelsyd ta lol raises to $54
MaXXXstaKd calls $36
*** FLOP *** [Tc 7h Kd]
aixelsyd ta lol bets $84
MaXXXstaKd calls $84
*** TURN *** [Tc 7h Kd] [4h]
aixelsyd ta lol checks
MaXXXstaKd checks
*** RIVER *** [Tc 7h Kd 4h] [5s]
aixelsyd ta lol checks
MaXXXstaKd bets $276
aixelsyd ta lol calls $276
*** SHOW DOWN ***
MaXXXstaKd shows [8s 9d] (King Ten high)
aixelsyd ta lol shows [6s 6d] (a pair of Sixes)
aixelsyd ta lol wins the pot ($827.50) with a pair of Sixes
*** SUMMARY ***
Total pot $828 | Rake $0.50
Board: [Tc 7h Kd 4h 5s]
Seat 1: MaXXXstaKd (small blind) showed [8s 9d] and lost with King Ten high
Seat 2: aixelsyd ta lol (big blind) showed [6s 6d] and won ($827.50) with a pair of Sixes
I was 95% sure he had 89 or QJ there.
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