I play some 9 handed stars cash games from 5/10-25/50 when the 6max games are literally filled with a table full of pros. Usually, the games are much better than 6max (at least for the higher stakes games. Game quality is probably similar for 100nl and below), but there are less decisions to be made since you have to play tighter and it is generally more boring since you have to wait for hands.
If you've never played 6max, I wouldn't advice playing it. Play some full ring cash games, figure it out and win at it, then switch to 6max. It's pretty similar, but you'll be able to play more hands against the bad players in 6max than you would in full ring.
And if you want to play the crack cocaine of hold 'em, try out some HU.
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